Berserker's Mayhem

Does Mayhem cap damage reduction? so like endurance wouldn’t do anything? or very VERY little?

No, it doesn’t.
You can combine Heavy Armor Engraving with Mayhem. That gives you about 80%+ damage reduction. (I’m using an Ability Stone with Masters Tentacy and Heavy Armor). Also in late game, card decks with DR are also recomended, like Natures Elementals and others. Also there are elemental damage reduction, that will be important in late game.
Probably there is dimishing return and a softcap, but you wont reach it that fast.

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It’s multiplicative, so get some but diminishes the higher you push it up.

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Thanks you two! that really helps <3